TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and a moderately potent IGF-1R inhibitor (IC50 of 140 nM). TAE 226 was also found to be effective as inhibitor for Pyk2 (with a reported IC50 of 3.5 nM) and insulin receptor (InsR) (with a reported IC50 of 44 nM). Furthermore TAE226 was also found to induce apoptosis.

KEYWORDS: TAE226 | Supplier | FAK and IGF-1R inhibitor | NVP-TAE226 | TAE-226 | TAE 226 | NVP-TAE-226 | NVP-TAE 226 | CT-TAE226 | CAS [761437-28-9] | Non Selective (Phosphorylation substrates) | FAK | IGF-1R | Inhibitor | Enzymes