AHU-377 is a prodrug which is activated in vivo by hydrolytic enzyme esterases to form an active compound LBQ657 that selectively and potently inhibits the enzyme Neprilysin with Ki at low nM. Neprilysin is a protease responsible for the degradation of atrial and brain natriuretic peptides. Inhibition of the enzyme prevents the degradation of natriuretic peptides and activates cGMP signaling pathways that regulate volume and blood pressure. AHU-377 is an investigational antihypertensive drug being studied for use in combination with Valsartan (Axon 3106) in a molar ratio of 1:1.

KEYWORDS: AHU-377 tris salt | Supplier | NEP inhibitor | Sacubitril tris salt | AHU377 | AHU 377 | CT-AHU377 | CAS [565453-99-8] | [149709-62-6] | Endothelin;Non Selective | NEP | Inhibitor | Enzymes