AZD-4205 - Golidocitinib

Based on 66 reference(s) in Google Scholar 8 10 66

Axon 3855

CAS [2091134-68-6]

MF C25H31N9O2
MW 489.57

  • Purity: 99%
  • Optical purity: 100% e.e.
  • Soluble in DMSO



AZD-4205 is a potent, selective and ATP-competitive inhibitor of JAK1 with a Ki of 2.8 nM, highly selective against JAK2 (IC50 =13233 nM, >4000 fold selectivity) and JAK3 (IC50 >30000 nM, >10000 fold selectivity). Demonstrates potent inhibition of p-STAT3 in a cell based assay of JAK1 activity with an IC50 of 128 nM and excellent selectivity across the kinome. Exhibits excellent pharmacokinetics, and in vitro and in vivo antitumor efficacy.

KEYWORDS: AZD-4205 | Supplier | JAK1 inhibitor | Golidocitinib | AZD4205 | AZD 4205 | CT-A4205 | CAS [2091134-68-6] | JAK-STAT Pathway | JAK | Inhibitor | Enzymes

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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