AZD-4205 is a potent, selective and ATP-competitive inhibitor of JAK1 with a Ki of 2.8 nM, highly selective against JAK2 (IC50 =13233 nM, >4000 fold selectivity) and JAK3 (IC50 >30000 nM, >10000 fold selectivity). Demonstrates potent inhibition of p-STAT3 in a cell based assay of JAK1 activity with an IC50 of 128 nM and excellent selectivity across the kinome. Exhibits excellent pharmacokinetics, and in vitro and in vivo antitumor efficacy.

KEYWORDS: AZD-4205 | Supplier | JAK1 inhibitor | Golidocitinib | AZD4205 | AZD 4205 | CT-A4205 | CAS [2091134-68-6] | JAK-STAT Pathway | JAK | Inhibitor | Enzymes