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BMS-599626 - AC480

Based on 29 reference(s) in Google Scholar 8 10 29

Axon 3853

CAS [714971-09-2]

MF C27H27FN8O3
MW 530.55

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO
Recently added

BMS-599626

Description

BMS-599626 is an orally bioavailable, potent and selective EGFR and ErbB2 inhibitor with IC50 values of 22 nM and 32 nM respectively, and inhibits HER4 with reduced potency (IC50 = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. It is an antiproliferative agent in vitro and anti-tumorigenic agent in vivo.

KEYWORDS: BMS-599626 | EGFR and ErbB2 inhibitor | AC480 | BMS599626 | BMS 599626 | AC-480 | AC 480 | CT-BMS59 | CAS [714971-09-2] | Non Selective (Phosphorylation substrates) | EGFR | ErbB2-HER2 | ErbB4-HER4 | Inhibitor | Receptors

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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