BMS-599626 is an orally bioavailable, potent and selective EGFR and ErbB2 inhibitor with IC50 values of 22 nM and 32 nM respectively, and inhibits HER4 with reduced potency (IC50 = 190 nM). Inhibits EGFR and ErbB2 with 100-fold greater potency than MEK and Lck. It is an antiproliferative agent in vitro and anti-tumorigenic agent in vivo.

KEYWORDS: BMS-599626 | EGFR and ErbB2 inhibitor | AC480 | BMS599626 | BMS 599626 | AC-480 | AC 480 | CT-BMS59 | CAS [714971-09-2] | Non Selective (Phosphorylation substrates) | EGFR | ErbB2-HER2 | ErbB4-HER4 | Inhibitor | Receptors