GSK-923295 is a first-in-class high affinity antimitotic inhibitor of centromere-associated protein E (CENP-E), potently and allosterically inhibiting CENP-E ATPase activity with a Ki value of 3.2 nM. Display a broad-spectrum antiproliferative activity against a range of human tumor xenografts grown in nude mice, including models of colon, breast, ovarian, lung and other tumors.

KEYWORDS: GSK923295 | Supplier | CENP-E Inhibitor | GSK-923295 | GSK 923295 | CT-GSK923 | CAS [1088965-37-0] | Microtubules | CENP-E | inhibitor | Enzymes