Oprozomib - ONX-0912 | PR-047

Based on 100 reference(s) in Google Scholar 8 10 100

Axon 3849

CAS [935888-69-0]

MF C25H32N4O7S
MW 532.61

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO



Oprozomib, a tripeptide epoxyketone, is an orally active and irreversible inhibitor of 20S proteasome, targeting primarily chymotrypsin-like activity. It inhibits growth and induces apoptosis in MM (multiple myeloma) cells resistant to conventional and bortezomib therapies. Its anti-MM activity is associated with activation of caspase-8, caspase-9, caspase-3, and poly(ADP) ribose polymerase, as well as inhibition of migration of MM cells and angiogenesis.

KEYWORDS: Oprozomib | Supplier | Proteasome inhibitor | ONX-0912 | PR-047 | ONX0912 | ONX 0912 | PR047 | PR 047 | CT-OPRO | CAS [935888-69-0] | Non Selective (Ubiquitin peptides) | Proteasome 20S | Inhibitor | Enzymes

Orally active and irreversible inhibitor of 20S proteasome

Chemical name


Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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