VX-11e - ERK11e

Based on 34 reference(s) in Google Scholar 8 10 34

Axon 3836

CAS [896720-20-0]

MF C24H20Cl2FN5O2
MW 500.35

  • Purity: 99%
  • Optical purity: >99% e.e.
  • Soluble in DMSO
Recently added

VX-11e

Description

Extracellular signal regulated kinase (ERK) is a pivotal enzyme in the pathway downstream of Ras, Raf, and MEK, acting as a central link between multiple signaling pathways. VX-11e (or ERK 11e) is a potent, selective, and orally bioavailable inhibitor of ERK2 with Ki < 2 nM, exhibiting potent cellular activity (IC50=48 nM in an HT29 cell proliferation assay). It is highly selective against a panel of more than 140 other kinases - most notably, GSK3 (Ki = 400nM), AURA (Ki = 540nM), CDK2 (Ki = 850nM), FLT3 (Ki = 1400nM), ROCK1 (Ki = 1400nM), and JNK3 (Ki = 1400nM).

KEYWORDS: VX-11e | ERK2 inhibitor | ERK11e | VX-11e | VX 11e | ERK-11e | ERK 11e | CT-VX11e | CAS [896720-20-0] | MAPK | ERK | Inhibitor | Enzymes

Potent, selective, and orally bioavailable inhibitor of ERK2

Chemical name

(S)-4-(2-(2-chloro-4-fluorophenylamino)-5-methylpyrimidin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[896720-20-0]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...