BAY-1816032

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3832

CAS [1891087-61-8]

MF C27H24F2N6O4
MW 534.51

  • Purity: 99%
  • Soluble in DMSO
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BAY-1816032

Description

BAY-1816032 is an orally available, highly potent and selective BUB1 (Mitotic checkpoint serine/threonine-protein kinase) inhibitor, with an enzymatic IC50 of 7 nM, and highly selective against other 395 kinases. Mechanistically BAY 1816032 abrogated nocodazole-induced Thr-120 phosphorylation of the major BUB1 target protein histone H2A in HeLa cells with an IC50 of 29 nM, induced lagging chromosomes and mitotic delay. Demonstrated in vitro and in vivo antitumor efficacy when applied in combination with taxanes.

KEYWORDS: BAY-1816032 | Supplier | BUB1 inhibitor | BAY1816032 | BAY 1816032 | CT-BAY181 | CAS [1891087-61-8] | BUB | Inhibitor | Enzymes

Potent and selective BUB1 (Mitotic checkpoint serine/threonine-protein kinase) inhibitor

Chemical name

2-(3,5-Difluoro-4-((3-(5-methoxy-4-(3-methoxypyridin-4-ylamino)pyrimidin-2-yl)-1H-indazol-1-yl)methyl)phenoxy)ethanol

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1891087-61-8]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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