MLN7243 - TAK-243 | AOB 87172

Based on 28 reference(s) in Google Scholar 8 10 28

Axon 3829

CAS [1450833-55-2]

MF C19H20F3N5O5S2
MW 519.52

  • Purity: 99%
  • Optical purity: 99%
  • Soluble in DMSO
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MLN7243

Description

MLN7243 is a cell permeable small molecule inhibitor targeting ubiquitin-activating enzymes (UAE, also known as E1 enzymes). The enzymes, found more active in cancer cells than in normal, healthy cells, catalyze the first step in ubiquitination reaction, targeting a protein for degradation via Proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Inhibition of the enzyme prevents both protein ubiquitination and subsequent ubiquitin-mediated proteasomal degradation, resulting in an excess of proteins in the cells that may lead to endoplasmic reticulum (ER) stress-mediated apoptosis, thus inhibit tumor (cancer) cell proliferation and survival.

KEYWORDS: MLN7243 | Supplier | Uubiquitin-activating enzymes (UAE) Inhibitor | TAK-243 | AOB 87172 | MLN-7243 | MLN 7243 | TAK243 | TAK 243 | AOB87172 | AOB-87172 | CT-M7243 | CAS [1450833-55-2] | Non Selective (Ubiquitin peptides) | Ubiquitin Ligase (E1) | Inhibitor | Enzymes

Cell permeable small molecule inhibitor targeting ubiquitin-activating enzymes (UAE, also known as E1 enzymes)

Chemical name

((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-(3-(trifluoromethylthio)phenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1450833-55-2]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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