MLN7243 is a cell permeable small molecule inhibitor targeting ubiquitin-activating enzymes (UAE, also known as E1 enzymes). The enzymes, found more active in cancer cells than in normal, healthy cells, catalyze the first step in ubiquitination reaction, targeting a protein for degradation via Proteasome. This covalent attachment of ubiquitin or ubiquitin-like proteins to targeted proteins is a major mechanism for regulating protein function in eukaryotic organisms. Inhibition of the enzyme prevents both protein ubiquitination and subsequent ubiquitin-mediated proteasomal degradation, resulting in an excess of proteins in the cells that may lead to endoplasmic reticulum (ER) stress-mediated apoptosis, thus inhibit tumor (cancer) cell proliferation and survival.

KEYWORDS: MLN7243 | Supplier | Uubiquitin-activating enzymes (UAE) Inhibitor | TAK-243 | AOB 87172 | MLN-7243 | MLN 7243 | TAK243 | TAK 243 | AOB87172 | AOB-87172 | CT-M7243 | CAS [1450833-55-2] | Non Selective (Ubiquitin peptides) | Ubiquitin Ligase (E1) | Inhibitor | Enzymes