TEAD inhibitor TM2 is a potent reversible pan-TEAD inhibitor with strong modulation of TEAD-YAP/TAZ transcriptional activities. TM2 exhibits strong inhibition of TEAD2 and TEAD4 auto-palmitoylation with IC50 values of 156 nM and 38 nM, respectively. Also, TM2 significantly inhibits YAP-dependent liver organoid growth ex vivo and inhibits proliferation of YAP-dependent cancer cells as a single agent or in combination with a MEK inhibitor.

KEYWORDS: TEAD inhibitor TM2 | Supplier | TEAD inhibitor | TM 2 | TM-2 | CAS [1008768-41-9] | Hippo signaling pathway | YAP | Inhibitor | Transcription Factors | TEAD-YAP