TEAD inhibitor TM2

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3824

CAS [1008768-41-9]

MF C26H33N3O3
MW 435.56

  • Purity: 99%
  • Soluble in DMSO and EtOH

TEAD inhibitor TM2


TEAD inhibitor TM2 is a potent reversible pan-TEAD inhibitor with strong modulation of TEAD-YAP/TAZ transcriptional activities. TM2 exhibits strong inhibition of TEAD2 and TEAD4 auto-palmitoylation with IC50 values of 156 nM and 38 nM, respectively. Also, TM2 significantly inhibits YAP-dependent liver organoid growth ex vivo and inhibits proliferation of YAP-dependent cancer cells as a single agent or in combination with a MEK inhibitor.

KEYWORDS: TEAD inhibitor TM2 | Supplier | TEAD inhibitor | TM 2 | TM-2 | CAS [1008768-41-9] | Hippo signaling pathway | YAP | Inhibitor | Transcription Factors | TEAD-YAP

Size Unit Price Stock
10 mg €130.00 In Stock
50 mg €520.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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