(+)-JQ1 carboxylic acid

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 3822

CAS [202592-23-2]

MF C19H17ClN4O2S
MW 400.88

Purity: 99%
Soluble 0.1N NaOH(aq), DMSO and EtOH

(+)-JQ1 carboxylic acid

Description

(+)-JQ1 carboxylic acid is a derivative of (+)-JQ1 (Axon 1989), which is a potent and selective BET bromodomain inhibitor. (+)-JQ1 carboxylic acid can be used as a precursor to synthesize PROTACs, which target BET bromodomains.

M Zengerle et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

GE Winter et al. DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 Jun 19;348(6241):1376-81.

(+)-JQ1 derivative; PROTAC precursor

Chemical name

(S,Z)-2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetic acid

Parent CAS No.

[202592-23-2]

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Size	Unit Price	Stock
10 mg	€110.00	In Stock
50 mg	€390.00	In Stock

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Related Products

Axon ID	Name	Description
1887	PFI-1	BET bromodomain (BRD) inhibitor	€75.00
1989	(+)-JQ1	Potent and selective BET bromodomain inhibitor	€60.00
2245	RVX 208	BET bromodomain inhibitor specific for second bromodomains (BD2s)	€65.00
2530	OTX 015	Potent inhibitor of BRD2, BRD3, and BRD4 with clear anti-proliferative activity	€110.00
2594	CPI 0610	Selective and metabolically stable inhibitor of BET bromodomains	Inquire
2776	CD161	Potent, selective, and orally active BET bromodomain inhibitor	€135.00
3037	BI-894999	Potent, selective and orally active BET inhibitor	€165.00
3329	ODM-207	Highly potent, selective and orally active pan-BET inhibitor	€140.00
3716	BMS-986158	BET bromodomain (BRD) inhibitor	Inquire
3696	ABBV-075	Highly potent and orally bioavailable BET bromodomain (BRD) inhibitor	€110.00
3833	AZD5153 HNT salt	Potent, selective, and orally available BET/BRD4 bromodomain inhibitor	Inquire
3873	(-)-JQ-1	Inactive enantiomer of (+)-JQ1	€120.00

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(+)-JQ1 carboxylic acid

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(+)-JQ1 carboxylic acid

Description

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