AZD4320

Based on 9 reference(s) in Google Scholar 8 10 9

Axon 3814

CAS [1357576-48-7]

MF C45H48ClF3N4O7S3
MW 945.53

  • Purity: 99%
  • Optical purity: 100% (e.e. and d.e.)
  • Soluble in DMSO
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AZD4320

Description

AZD4320 is a BH3 mimetic and highly potent dual Bcl-2/Bcl-XL inhibitor with binding affinity in low nanomolar range similar to ABT-263 (Axon 3821), but with a better therapeutic index (lower toxicities) and amenable to I. V. administration. It rapidly induces caspase-3 (CC3) cleavage and cell death in both Bcl-2-driven (SuDHL4, GI50 24 days) tumor regressions in a mouse RS4;11 acute lymphocytic leukemia xenograft model (20 mg/kg, i.v.).

KEYWORDS: AZD4320 | Supplier | BH3-mimetic inhibitor of BCL-2 protein | AZD-4320 | AZD 4320 | CT-A4320 | CAS [1357576-48-7] | Non Selective | Bcl | Inhibitor | Proteins

BH3-mimetic inhibitor of BCL-2 protein

Chemical name

4-(4-((R)-(4'-Chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)-N-(4-((R)-4-((2-hydroxyethyl)(methyl)amino)-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1357576-48-7]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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