AZD3458

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3808

CAS [2132961-46-5]

MF C20H23N3O4S2
MW 433.54

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO
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AZD3458

Description

AZD3458 is an orally bioavailable potent and selective PI3Kγ inhibitor, and an immuno-oncology modulator. It selectively inhibits PI3Kγ with a cellular IC50 of 8 nM, a 100-fold selective over PI3Kδ in vitro, AZD3458 inhibits pAKTS308/S473 in human macrophages and mouse CD11b activation at 32nM and 30nM free IC50 respectively. Application of AZD3458 in vivo with checkpoint inhibitors α-PD-1 or α-PD-L1 had greater anti-tumor effects than checkpoint inhibitor alone in 4T1, LLC, CT-26 and MC-38 mouse syngeneic models, suggesting that AZD3458 can reverse myeloid suppressive tumor microenvironment and revert tumor resistance to immunotherapy in myeloid-enriched immunosuppressive tumor types.

KEYWORDS: AZD3458 | Supplier | PI3Kγ inhibitor | AZD-3458 | AZD 3458 | CT-A3458 | CAS [2132961-46-5] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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