GS-9901

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3807

CAS [1640247-87-5]

MF C22H17ClFN9O
MW 477.88

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO
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GS-9901

Description

GS-9901 is an orally active, potent and isoform-selective inhibitor of PI3Kδ (PI3Kδ IC50 = 1.0 nM, HWB δ EC50 = 1.5 nM; CLpr hHep = 0.05 L/h/kg.), and a potential immunomodulating agent. It is highly selective against other isoforms: p110α (750 nM), p110β (100 nM) and P110γ (190 nM).

KEYWORDS: GS-9901 | Supplier | PI3Kδ inhibitor | GS9901 | GS 9901 | CT-GS9901 | CAS [1640247-87-5] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes

Potent and isoform-selective inhibitor of PI3Kδ

Chemical name

(S)-2,4-diamino-6-((5-chloro-8-fluoro-4-oxo-3-(pyridin-3-yl)-3,4-dihydroquinazolin-2-yl)(cyclopropyl)methylamino)pyrimidine-5-carbonitrile

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1640247-87-5]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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