JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize the functionality of this website.
There are no items in your shopping cart
Featured Products
Axon 3803
CAS [1184173-73-6]
MF C37H41N9O3SMW 691.84
SCH900353 is an orally bioavailable potent inhibitor targeting activated ERK1/2 with IC50 values of 23.0 and 8.8 nM, respectively, and nonactivated ERK2 with IC50 of 0.5 nM, highly selective over a panel of 227-human kinase; decreases levels of pERK1, pERK2, and ribosomal S6 kinase (pRSK) protein formation, with complete suppression of pERK1 and pERK2 observed at 30 nM in A2058 cells; inhibits the in vitro proliferation of a panel of BRAFV600-mutant and RAS-mutant cancer cell lines; displays in vivo antitumor efficacy against BRAFV600 mutant Colo-205 colon cancer model and the BRAFV600 mutant SK-MEL-28 melanoma model.
KEYWORDS: SCH900353 | Supplier | ERK1/2 inhibitor | MK 8353 | SCH-900353 | SCH 900353 | MK8353 | MK 8353 | CT-SCH353 | CAS [1184173-73-6] | ERK | MAKK | Inhibitor | Enzymes
(S)-N-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-5,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide
[1184173-73-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
* Required Fields