SCH900353 - MK 8353

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Axon 3803

CAS [1184173-73-6]

MF C37H41N9O3S
MW 691.84

  • Purity: 99%
  • Optical purity: 99%
  • Soluble in DMSO
Recently added

SCH900353

Description

SCH900353 is an orally bioavailable potent inhibitor targeting activated ERK1/2 with IC50 values of 23.0 and 8.8 nM, respectively, and nonactivated ERK2 with IC50 of 0.5 nM, highly selective over a panel of 227-human kinase; decreases levels of pERK1, pERK2, and ribosomal S6 kinase (pRSK) protein formation, with complete suppression of pERK1 and pERK2 observed at 30 nM in A2058 cells; inhibits the in vitro proliferation of a panel of BRAFV600-mutant and RAS-mutant cancer cell lines; displays in vivo antitumor efficacy against BRAFV600 mutant Colo-205 colon cancer model and the BRAFV600 mutant SK-MEL-28 melanoma model.

KEYWORDS: SCH900353 | Supplier | ERK1/2 inhibitor | MK 8353 | SCH-900353 | SCH 900353 | MK8353 | MK 8353 | CT-SCH353 | CAS [1184173-73-6] | ERK | MAKK | Inhibitor | Enzymes

ERK1/2 inhibitor

Chemical name

(S)-N-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-5,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1184173-73-6]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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