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Axon 3761
CAS [2621928-55-8]
MF C33H31F3N6O2MW 600.63
MRTX1133 is a first-in-class, noncovalent, selective & reversible inhibitor of KRASG12D mutant in both active and inactive states. Demonstrates selective inhibition of cell viability of KRASG12D mutant, but not KRAS wild-type, tumor cells. Displays sustained dose-dependent inhibition of KRAS-dependent signaling in mouse tumor models.
KEYWORDS: MRTX1133 | Supplier | KRASG12D mutant inhibitor | MRTX 1133 | MRTX-1133 | CT-MTX1133 | CAS [2621928-55-8] | GTP | KRAS | Inhibitor | Enzymes
4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol
[2621928-55-8]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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