LY-3295668 - AK-01

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Axon 3758

CAS [1919888-06-4]

MF C24H26ClF2N5O2
MW 489.95

  • Purity: 99%
  • Optical purity: 99
  • Soluble in DMSO
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LY-3295668

Description

LY3295668 is an orally available, potent and highly selective Aurora A kinase (AurA) inhibitor with Ki of 0.8 nM, and H446 AurA auto-P IC50 of 0.6 nM, highly selective (>1000 fold) over Aurora B. LY3295668 is cytotoxic to RB1 mutant cancer cells (NCI-H446 cell IC50 = 0.752 uM), and achieves durable regression of RB1mut tumor xenografts.

* Sold in collaboration with Chemietek.

KEYWORDS: LY-3295668 | Supplier | Aurora A inhibitor | AK-01 | LY3295668 | LY 3295668 | AK01 | AK 01 | CT-LY3295 | CAS [1919888-06-4] | Non Selective (LIM;p53;TPX2) | Aurora | Inhibitor | Enzymes

Orally available, potent and highly selective Aurora A kinase (AurA) inhibitor

Chemical name

(2R,4R)-1-(3-Chloro-2-fluorobenzyl)-4-((3-fluoro-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)-2-methylpiperidine-4-carboxylic acid

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1919888-06-4]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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