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Axon 3758
CAS [1919888-06-4]
MF C24H26ClF2N5O2MW 489.95
LY3295668 is an orally available, potent and highly selective Aurora A kinase (AurA) inhibitor with Ki of 0.8 nM, and H446 AurA auto-P IC50 of 0.6 nM, highly selective (>1000 fold) over Aurora B. LY3295668 is cytotoxic to RB1 mutant cancer cells (NCI-H446 cell IC50 = 0.752 uM), and achieves durable regression of RB1mut tumor xenografts.
KEYWORDS: LY-3295668 | Supplier | Aurora A inhibitor | AK-01 | LY3295668 | LY 3295668 | AK01 | AK 01 | CT-LY3295 | CAS [1919888-06-4] | Non Selective (LIM;p53;TPX2) | Aurora | Inhibitor | Enzymes
(2R,4R)-1-(3-Chloro-2-fluorobenzyl)-4-((3-fluoro-6-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2-yl)methyl)-2-methylpiperidine-4-carboxylic acid
[1919888-06-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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