GSK3685032 hydrochloride

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 3757

CAS [2170140-51-7]

MW 457.00

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in 0.1 HCl(aq) and DMSO

GSK3685032 hydrochloride


GSK3685032 hydrochloride is a potent first-in-class DNMT1-selective inhibitor. Induces robust loss of DNA methylation, transcriptional activation and cancer cell growth inhibition in vitro. Displays a much-improved in vivo tolerability and greater DNA hypomethylation compared with decitabine, translating into superior tumor regression and survival mouse models of acute myeloid leukemia.

KEYWORDS: GSK3685032 hydrochloride | Supplier | DNMT1 inhibitor | GSK-3685032 | GSK3685032 | 2170137-61-6 | CT-GSK368 | CAS [2170140-51-7] | [2170140-50-6] | DNA-RNA | DNA methyltransferase | Inhibitor | Enzymes

Potent first-in-class DNMT1-selective inhibitor

Chemical name

(R)-2-(6-(4-aminopiperidin-1-yl)-3,5-dicyano-4-ethylpyridin-2-ylthio)-2-phenylacetamide hydrochloride

Source information

Sold in collaboration with Chemietek

Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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