GSK3685032 hydrochloride is a potent first-in-class DNMT1-selective inhibitor. Induces robust loss of DNA methylation, transcriptional activation and cancer cell growth inhibition in vitro. Displays a much-improved in vivo tolerability and greater DNA hypomethylation compared with decitabine, translating into superior tumor regression and survival mouse models of acute myeloid leukemia.

KEYWORDS: GSK3685032 hydrochloride | Supplier | DNMT1 inhibitor | GSK-3685032 | GSK3685032 | 2170137-61-6 | CT-GSK368 | CAS [2170140-51-7] | [2170140-50-6] | DNA-RNA | DNA methyltransferase | Inhibitor | Enzymes