Your cart

There are no items in your shopping cart

JNJ-64619178 dihydrochloride - Onametostat dihydrochloride

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 3754

CAS [N.A.]

MF C22H23BrN6O2.2HCl
MW 556.28

  • Purity: 99%
  • Optical purity: 99% d.e.
  • Soluble in water and DMSO

JNJ-64619178 dihydrochloride

Description

JNJ-64619178 is a SAM-pocket binding (SAM Competitive) PRMT5 inhibitor with high selectivity and potency (PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions. Demonstrates tumor regression in a biomarker-driven human small cell lung cancer xenograft model (NCI-H1048) and prolongs tumor growth inhibition after dosing cessation.

KEYWORDS: JNJ-64619178 | Supplier | PRMT5 inhibitor | Onametostat dihydrochloride | JNJ64619178 | JNJ-64619178 | CAS [N.A.] | [2086772-26-9] | Non Selective (Arginine sites proteins) | PRMT | Inhibitor | Enzymes

SAM-pocket binding (SAM Competitive) PRMT5 inhibitor

Chemical name

(1S,2R,3S,5R)-3-(2-(2-amino-3-bromoquinolin-8-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol dihydrochloride

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[2086772-26-9]

Related Products

Axon ID Name Description From price
2709 CMP5 Inhibitor of PRMT5 €95.00
2710 HLCL65 hydrochloride Inhibitor of PRMT5 €105.00
2831 EPZ 015666 Potent, selective and orally available inhibitor of PRMT5 €125.00
3692 PF-06939999 dihydrochloride SAM competitive PRMT5 inhibitor Inquire
3750 GSK3326595 Orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5) Inquire
3796 MRTX1719 hydrochloride Inhibitor of the PRMT5.MTA complex Inquire
3798 PF-06855800 SAM-pocket-binding (SAM competitive) PRMT5 inhibitor Inquire
3919 GSK3368715 hydrochloride A first-in-class, orally active, potent and selective, SAM-Noncompetive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs) Inquire

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Newsletter
Give Feedback
 
Send E-mail

Customer Support

About Axon Medchem

Download Product Catalog

Download the Axon Ligands™ catalogue 2021 Spring Edition

Follow Us

© 2016 Axon Medchem. All Rights Reserved.

Send us a message

×

Contact Us

* Required Fields

Please wait...