JNJ-64619178 dihydrochloride - Onametostat dihydrochloride

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 3754

CAS [N.A.]

MF C22H23BrN6O2.2HCl
MW 556.28

  • Purity: 99%
  • Optical purity: 99% d.e.
  • Soluble in water and DMSO

JNJ-64619178 dihydrochloride


JNJ-64619178 is a SAM-pocket binding (SAM Competitive) PRMT5 inhibitor with high selectivity and potency (PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions. Demonstrates tumor regression in a biomarker-driven human small cell lung cancer xenograft model (NCI-H1048) and prolongs tumor growth inhibition after dosing cessation.

KEYWORDS: JNJ-64619178 | Supplier | PRMT5 inhibitor | Onametostat dihydrochloride | JNJ64619178 | JNJ-64619178 | CAS [N.A.] | [2086772-26-9] | Non Selective (Arginine sites proteins) | PRMT | Inhibitor | Enzymes

SAM-pocket binding (SAM Competitive) PRMT5 inhibitor

Chemical name

(1S,2R,3S,5R)-3-(2-(2-amino-3-bromoquinolin-8-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol dihydrochloride

Source information

Sold in collaboration with Chemietek

Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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