NVP-CGM097 - CGM097

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Axon 3751

CAS [1313363-54-0]

MF C38H47ClN4O4
MW 659.26

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO
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NVP-CGM097

Description

NVP-CGM097 is a potent and selective MDM2 inhibitor. Optically pure (S-Enantiomer) NVP-CGM097 binds to the p53 binding-site of the Human MDM2 protein with an IC50 value of 1.7 nM, highly selective against other protein-protein interactions such as p53:MDM4 (>1000-fold selectivity), Ras:Raf (3000-fold selectivity), and showing no significant activity against Bcl-2:Bak, Bcl-2:Bad, Mcl-1:Bak, Mcl-1:NOXA, XIAP:BIR3, and c-IAP:BIR3 protein−protein interactions. It inhibits the p53:MDM2 interaction in cells, leading to p53 nuclear translocation that results in cell growth inhibition in a p53-dependent manner. Exhibit excellent in vivo pharmacological properties. The dihydrochloride salt of NVP-CGM097 is available as Axon 3752.

* Sold in collaboration with Chemietek.

KEYWORDS: NVP-CGM097 | Supplier | MDM2 inhibitor | NVPCGM097 | NVP-CGM097 | CGM 097 | CGM-097 | CT-CGMFB | CAS [1313363-54-0] | p53 | HDM-MDM | Inhibitor | Enzymes

Inhibitor of MDM2

Chemical name

(S)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4r)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1313363-54-0]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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