NVP-CGM097 is a potent and selective MDM2 inhibitor. Optically pure (S-Enantiomer) NVP-CGM097 binds to the p53 binding-site of the Human MDM2 protein with an IC50 value of 1.7 nM, highly selective against other protein-protein interactions such as p53:MDM4 (>1000-fold selectivity), Ras:Raf (3000-fold selectivity), and showing no significant activity against Bcl-2:Bak, Bcl-2:Bad, Mcl-1:Bak, Mcl-1:NOXA, XIAP:BIR3, and c-IAP:BIR3 protein−protein interactions. It inhibits the p53:MDM2 interaction in cells, leading to p53 nuclear translocation that results in cell growth inhibition in a p53-dependent manner. Exhibit excellent in vivo pharmacological properties. The dihydrochloride salt of NVP-CGM097 is available as Axon 3752.

KEYWORDS: NVP-CGM097 | Supplier | MDM2 inhibitor | NVPCGM097 | NVP-CGM097 | CGM 097 | CGM-097 | CT-CGMFB | CAS [1313363-54-0] | p53 | HDM-MDM | Inhibitor | Enzymes