GSK3326595 - Pemrametostat | EPZ015938

Based on 12 reference(s) in Google Scholar 8 10 12

Axon 3750

CAS [1616392-22-3]

MF C24H32N6O3
MW 452.55

  • Purity: 99%
  • Optical purity: 99%
  • Soluble in DMSO
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GSK3326595

Description

GSK3326595 is an orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5)/MEP50 with a biochemical IC50 of 6 nM, and is >4,000-fold selective for PRMT5/MEP50 over any other enzyme when tested in a panel containing 20 other histone methyltransferases. Display potent antitumor activities in vitro and in vivo in animal models.

* Sold in collaboration with Chemietek.

KEYWORDS: GSK3326595 | Supplier | PRMT5 inhibitor | Pemrametostat | EPZ015938 | GSK-3326595 | GSK 3326595 | EPZ-015938 | EPZ 015938 | CT-GSK332 | CAS [1616392-22-3] | Non Selective (Arginine sites proteins) | PRMT | Inhibitor | Enzymes

Orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5)

Chemical name

(S)-6-(1-Acetylpiperidin-4-ylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1616392-22-3]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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