GSK3326595 is an orally active, potent, selective, SAM uncompetitive, peptide competitive, slow binding inhibitor of protein arginine methyltransferase 5 (PRMT5)/MEP50 with a biochemical IC50 of 6 nM, and is >4,000-fold selective for PRMT5/MEP50 over any other enzyme when tested in a panel containing 20 other histone methyltransferases. Display potent antitumor activities in vitro and in vivo in animal models.

KEYWORDS: GSK3326595 | Supplier | PRMT5 inhibitor | Pemrametostat | EPZ015938 | GSK-3326595 | GSK 3326595 | EPZ-015938 | EPZ 015938 | CT-GSK332 | CAS [1616392-22-3] | Non Selective (Arginine sites proteins) | PRMT | Inhibitor | Enzymes