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Axon 3737
CAS [1448867-41-1]
MF C26H24Cl2N6O4MW 555.41
Siremadlinis an orally bioavailable, potent and selective inhibitor of p53-MDM2 interaction, binding to human MDM2 protein with a picomolar Ki value (0.21 nM). Highly selective against MDM4 protein (Ki = 3300 nM, >10000 fold selectivity). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.
KEYWORDS: Siremadlin | Supplier | MDM2 inhibitor | NVP-HDM201 | HDM-201 | NVP-HDM-201 | NVP-HDM 201 | CAS [1448867-41-1] | p53 | HDM-MDM | Inhibitor | Enzymes
(S)-5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one
[1448867-41-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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