HBX 41,108 is an inhibitor of USP7/HAUSP ubiquitin protease with an IC50 value of 424 nM. HBX 41,108 treatment stabilized p53, activated the transcription of a p53 target gene without inducing genotoxic stress, and inhibited cancer cell growth. Finally, HBX 41,108 induced p53-dependent apoptosis as shown in p53 wild-type and null isogenic cancer cell lines.

KEYWORDS: HBX 41,108 | Supplier | USP7 inhibitor | HBX41108 | HBX41,108 | HBX-41,108 | HBX 41108 | HBX-41108 | CAS [924296-39-9] | Non Selective (Ubiquitin peptides) | Deubiquitinase | Inhibitor | Enzymes | p53/Mdm2 | Ubiquitin-specific proteases