AZD5991

Based on 32 reference(s) in Google Scholar 8 10 32

Axon 3731

CAS [2143061-81-6]

MF C35H36ClN5O3S2
MW 674.28

  • Purity: 99%
  • Optical purity: 99% a.e.
  • Soluble in DMSO
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AZD5991

Description

AZD5991 is a potent and selective BH3-groove-binding Mcl-1 inhibitor with sub-nanomolar affinity for the target. It demonstrates all the hallmarks of a true Mcl-1 inhibitor: 1. potent, selective, and rapid apoptosis in Mcl-1-dependent cell lines (e.g., GI50 as low as 10 nM in multiple myeloma cell lines); 2. loss of activity upon overexpression of Bcl-xL or siRNA-mediated knockout of Bak; 3. Mcl-1:Bak complex disruption as demonstrated by co-immunoprecipitation. AZD5991 is active in vivo, with complete (100%) tumor regression demonstrated in several mouse xenograft models after a single tolerated dose.

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KEYWORDS: AZD5991 | Supplier | BH3-Groove binding Mcl-1 inhibitor | AZD-5991 | AZD 5991 | CT-A5991 | CAS [2143061-81-6] | Non Selective | Mcl-1 | Inhibitor | Proteins

BH3-Groove binding Mcl-1 inhibitor

Chemical name

17-Chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(36),4(38),6,11,14,16,18,20,23,29(37),30,32,34-tridecaene-23-carboxylic acid

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[2143061-81-6]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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