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Axon 3724
CAS [2285330-15-4]
MF C17H20BNO5MW 329.16
M-3258 is an orally-bioavailable potent and selective inhibitor of the immunoproteasome subunit LMP7 demonstrating >500-fold selectivity against β1c, β2c, β5c, β1i and β2i. M3258 displayed favorable pharmacokinetics and demonstrated strong LMP7 inhibition and anti-tumor activity in several multiple myeloma xenografts, including models that were refractory to Bortezomib.
KEYWORDS: M-3258 | Supplier | Proteasome inhibitor | M3258 | M 3258 | CAS [2285330-15-4] | Non Selective (Ubiquitin peptides) | Proteasome 26S | Inhibitor | Enzymes
(R)-2-(benzofuran-3-yl)-1-((1S,2R,4R)-7-oxabicyclo[2.2.1]heptane-2-carboxamido)ethylboronic acid
[2285330-15-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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