S63845

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Axon 3723

CAS [1799633-27-4]

MF C39H37ClF4N6O6S
MW 829.26

  • Purity: 99%
  • Optical purity: 99% e.e. and a.e.
  • Soluble in DMSO
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S63845

Description

S63845 is the first high affinity MCL-1 inhibitor with in vivo activity, binding to the BH3 groove of human MCL-1 with a KD value of 0.19 nM, highly selective against other BCL family proteins BCL-2 (Ki >10,000nM) and BCL-XL (Ki >10,000nM) (ref 1). S63845 showed the clear-on-target activity killing Mcl-1-dependent cancer cells, including multiple myeloma, leukemia and lymphoma cells. Demonstrated potent in vivo antitumor activity, with an acceptable safety margin, as a single agent in several cancer types.

* Sold in collaboration with Chemietek.

KEYWORDS: S63845 | Supplier | BH3-Groove binding Mcl-1 inhibitor | S-63845 | S 63845 | CT-S63845 | CAS [1799633-27-4] | Non Selective | Mcl-1 | Inhibitor | Proteins

BH3-Groove binding Mcl-1 inhibitor

Chemical name

(R)-2-((S)-5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1799633-27-4]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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