S63845 is the first high affinity MCL-1 inhibitor with in vivo activity, binding to the BH3 groove of human MCL-1 with a KD value of 0.19 nM, highly selective against other BCL family proteins BCL-2 (Ki >10,000nM) and BCL-XL (Ki >10,000nM) (ref 1). S63845 showed the clear-on-target activity killing Mcl-1-dependent cancer cells, including multiple myeloma, leukemia and lymphoma cells. Demonstrated potent in vivo antitumor activity, with an acceptable safety margin, as a single agent in several cancer types.

KEYWORDS: S63845 | Supplier | BH3-Groove binding Mcl-1 inhibitor | S-63845 | S 63845 | CT-S63845 | CAS [1799633-27-4] | Non Selective | Mcl-1 | Inhibitor | Proteins