Valemetostat - DS-3201B

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Axon 3722

CAS [1809336-39-7]

MF C26H34ClN3O4
MW 488.02

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO
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Valemetostat

Description

Valemetostat is an orally available potent and selective inhibitor of EZH1 and EZH2 (the histone lysine methyltransferases enhancer of zeste homolog 1 and 2) (both wild-type and mutated forms) with IC50s in nanomolar concentrations. Demonstrates anti-proliferative effect against various NHL (non-Hodgkin lymphomas) cells, such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma, and peripheral T-cell lymphoma, with GI50 values less than 100 nM regardless of EZH2 gain-of-function mutations; Induces differentiation of undifferentiated NHL cells with increment of cell lineage specific markers and which induced cell death in vitro; Shows synergistic effect with the standard of care agents for NHL in vitro and in vivo.

* Sold in collaboration with Chemietek.

KEYWORDS: Valemetostat | Supplier | EZH1/2 HMTase inhibitor | DS-3201B | CT-DS3201 | CAS [1809336-39-7] | Histone | HMTase | Inhibitor | Enzymes

Inhibitor of Histone Lysine Methyltransferase EZH1/2

Chemical name

(R)-7-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-((1r,4R)-4-(dimethylamino)cyclohexyl)-2,4-dimethylbenzo[d][1,3]dioxole-5-carboxamide

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1809336-39-7]

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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