Valemetostat - DS-3201B

Based on 7 reference(s) in Google Scholar 8 10 7

Axon 3722

CAS [1809336-39-7]

MF C26H34ClN3O4
MW 488.02

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO



Valemetostat is an orally available potent and selective inhibitor of EZH1 and EZH2 (the histone lysine methyltransferases enhancer of zeste homolog 1 and 2) (both wild-type and mutated forms) with IC50s in nanomolar concentrations. Demonstrates anti-proliferative effect against various NHL (non-Hodgkin lymphomas) cells, such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma, and peripheral T-cell lymphoma, with GI50 values less than 100 nM regardless of EZH2 gain-of-function mutations; Induces differentiation of undifferentiated NHL cells with increment of cell lineage specific markers and which induced cell death in vitro; Shows synergistic effect with the standard of care agents for NHL in vitro and in vivo.

KEYWORDS: Valemetostat | Supplier | EZH1/2 HMTase inhibitor | DS-3201B | CT-DS3201 | CAS [1809336-39-7] | Histone | HMTase | Inhibitor | Enzymes

Inhibitor of Histone Lysine Methyltransferase EZH1/2

Chemical name


Source information

Sold in collaboration with Chemietek

Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...