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JAB-3068

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 3721

CAS [2169223-48-5]

MF C22H26F2N6O2S
MW 476.54

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO

JAB-3068

Description

JAB-3068 is a potent, selective and orally bioavailable allosteric inhibitor of SHP2 (protein tyrosine phosphatase) (PTP) non-receptor type 11 (SHP2; Src homology region 2 domain phosphatase; PTPN11), with potential antineoplastic activity. It is efficacious as an oral monotherapy as well as an immune-oncology modulator.

KEYWORDS: JAB-3068 | Supplier | SHP2 inhibitor | JAB3068 | JAB 3068 | CT-JAB3068 | CAS [2169223-48-5] | Non Selective (Tyrosine Specific Phosphomonoesters) | SHP | Inhibitor | Enzymes

SHP2 inhibitor

Chemical name

(S)-1-(4-(3-amino-5-(4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-ylthio)-3,3-difluoroindolin-1-yl)ethanone

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[2169223-48-5]

Order
Size Unit Price Stock
5 mg €240.00 In Stock
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Size Unit Price Stock
2 x 5 mg €380.00 In Stock
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3729 ABBV-CLS-484 hydrochloride Inhibitor of phosphatase PTPN1/N2 (Protein Tyrosine Phosphatase Non-Receptor Type 1 and 2), Inquire
3767 GDC-1971 Orally available, potent, and selective inhibitor of the protein tyrosine phosphatase SHP2 Inquire
3865 TNO155 Selective and orally bioavailable allosteric inhibitor of SHP2 Inquire
3868 RMC-4550 hydrochloride Potent, selective and orally available small molecule allosteric inhibitor of SHP2 Inquire
3903 IACS-13909 hydrochloride Potent and specific allosteric inhibitor of SHP2 Inquire

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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