AB-680 ammonium salt - Quemliclustat ammonium salt

Based on 6 reference(s) in Google Scholar 8 10 6

Axon 3718

CAS [N.A.]

MF C20H30ClFN6O9P2
MW 614.89

  • Purity: 99%
  • Optical purity: 99%
  • Soluble in DMSO and Water

AB-680 ammonium salt


AB-680 (Quemliclustat) is a highly potent and selective inhibitor of CD73 (Ki hCD73 = 4.9 pM on human CD8+ T-cells) and an immune-oncology modulator, highly selective against the closely-related CD39 (10,000-fold selectivity), and a large panel of unrelated enzymes, receptors, and ion channels. It potently reverses AMP and ADO-mediated suppression of immune function in vitro, robustly restores, in the presence high AMP concentration, CD25 expression, IFN-γ production and proliferation of human CD4+ and CD8+ T-cells, and reverses ADO-mediated immune suppression.

KEYWORDS: AB-680 ammonium salt | Supplier | CD73 inhibitor | Quemliclustat ammonium salt | AB680 | AB 680 | CT-AB680 | CAS [N.A.] | [2105904-82-1] | AMP | 5'-nucleotidase | Inhibitor | Enzymes

CD73 inhibitor

Chemical name

((((2R,3S,4R,5R)-5-(6-chloro-4-((S)-1-(2-fluorophenyl)ethylamino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methylphosphonic acid ammonium salt

Source information

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Parent CAS No.


The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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