AB-680 (Quemliclustat) is a highly potent and selective inhibitor of CD73 (Ki hCD73 = 4.9 pM on human CD8+ T-cells) and an immune-oncology modulator, highly selective against the closely-related CD39 (10,000-fold selectivity), and a large panel of unrelated enzymes, receptors, and ion channels. It potently reverses AMP and ADO-mediated suppression of immune function in vitro, robustly restores, in the presence high AMP concentration, CD25 expression, IFN-γ production and proliferation of human CD4+ and CD8+ T-cells, and reverses ADO-mediated immune suppression.

KEYWORDS: AB-680 ammonium salt | Supplier | CD73 inhibitor | Quemliclustat ammonium salt | AB680 | AB 680 | CT-AB680 | CAS [N.A.] | [2105904-82-1] | AMP | 5'-nucleotidase | Inhibitor | Enzymes