GSK2256098 is an orally bioavailable small molecule inhibitor of Focal adhesion kinase (FAK) (Ezymatic apparent Ki = 0.4 nM), targeting specifically at phosphorylation site of the enzyme, tyrosine (Y) 397 (FAK Y397). GSK2256098 inhibition of FAK Y397 phosphorylation correlated with decreased levels of phosphorylated Akt and ERK in L3.6P1 cells (Cellular IC50 = 2-15 nM), decreased cell viability, anchorage-independent growth, and motility in a dose dependent manner.

KEYWORDS: GSK2256098 | Supplier | FAK inhibitor | GSK-2256098 | GSK 2256098 | GTPL-7939 | GTPL 7939 | CT-GSK225 | CAS [1224887-10-8] | Non Selective (Phosphorylation Substrates) | FAK | Inhibitor | Enzymes