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BMS-986158

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3716

CAS [1800340-40-2]

MF C30H33N5O2
MW 495.62

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO

BMS-986158

Description

BMS-986158 is an orally bioavailable, potent and domain-selective BET protein inhibitor, binding to the acetyl-lysine binding site of BET bromodomain of BRD4 (Bromodomain-containing 4) with an IC50 < 5nM (FRET). Display excellent pharmacokinetic properties and efficacy in vitro and in vivo antitumor activity.

KEYWORDS: BMS-986158 | Supplier | BET bromodomain (BRD4) inhibitor | BMS986158 | BMS 986158 | CT-BMS986 | CAS [1800340-40-2] | Histone | BET (BRD) | Inhibitor | Proteins

BET bromodomain (BRD) inhibitor

Chemical name

(S)-2-(3-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-5-(phenyl(tetrahydro-2H-pyran-4-yl)methyl)-5H-pyrido[3,2-b]indol-7-yl)propan-2-ol

Source information

Sold in collaboration with Chemietek

Parent CAS No.

[1800340-40-2]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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