E-7386

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 3715

CAS [1799824-08-0]

MF C39H48FN9O4
MW 725.85

  • Purity: 99%
  • Optical purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO
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E-7386

Description

E-7386 (E7386) is a first-in-class orally active specific inhibitor of CBP/β-catenin complex, and a modulator of Wnt signaling pathway. It disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 in a dose-dependent manner, with IC50 of 55 and 73 nM, respectively; exhibits anti-tumor activity in vitro tumor proliferation panel against 28 human tumor cell lines; modulates the expression of Wnt signaling pathway related genes including AXIN2 and other genes. Oral administration of E7386 significantly suppressed the number of polyposis in a dose dependent manner at the dose range from 8.5 to 50 mg/kg. It also significantly changed the expressions of Wnt related genes in whisker follicle of ApcMin/+mice model.

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KEYWORDS: E-7386 | Supplier | CBP/beta-catenin modulator | E7386 | E 7386 | CT-E7386 | CAS [1799824-08-0] | ECM-adhesion | β-Catenin | Wnt | Modulator | Proteins

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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