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Axon 3713
CAS [1799631-75-6]
MF C47H44ClFN6O6SMW 875.41
MIK665 is a clinical-stage, BH3-Groove binding Mcl-1 inhibitor, potently and selectively binding to the protein target with Ki in picomolar range. Demonstrate in vitro and in vivo antitumor efficacy in Mcl-1 dependent cancer models. Achieve superior activity and enhanced solid tumor response when applied in combination with Bcl-2 inhibitors such as ABT-199 (Axon 2141) or BCL-201 (Axon 3714).
KEYWORDS: MIK665 | Supplier | BH3-Groove binding Mcl-1 inhibitor | MIK-665 | MIK-665 | S-64315 | S 64315 | CT-MIK665 | CAS [1799631-75-6] | Non Selective | Mcl-1 | Inhibitor | Proteins
(R)-2-((S)-5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid
[1799631-75-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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