AZD8186

Based on 21 reference(s) in Google Scholar 8 10 21

Axon 3690

CAS [1627494-13-6]

MF C24H25F2N3O4
MW 457.47

  • Purity: 99%
  • Optical purity: 99% e.e.
  • Soluble in DMSO
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AZD8186

Description

AZD8186 is a metabolically stable and pharmacologically excellent PI3Kβ/δ isoform-selective inhibitor. It is orally available, potent and selective. Enantiomerically pure AZD8186 inhibits PI3Kβ and PI3Kδ in cellular assays with IC50 values of 3 nM and 17 nM, respectively, highly selective over PI3Kα (IC50 = 752 nM). It has demonstrated a profound pharmacodynamics modulation of p-Akt in PTEN-deficient PC3 prostate tumor bearing mice after oral administration, and showed a complete inhibition of tumor growth in the mouse PTEN-deficient PC3 prostate tumor xenograft model.

* Sold in collaboration with Chemietek.

KEYWORDS: AZD8186 | Supplier | PI3K p110β/δ inhibitor | AZD 8186 | AZD-8186 | CT-A8186 | CAS [1627494-13-6] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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