MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human Type I Protein Arginine Methyltransferases (IC50 values 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively) completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. MS023 potently decreased cellular levels of histone arginine asymmetric dimethylation.

KEYWORDS: MS023 dihydrochloride | Supplier | PRMT inhibitor | MS 023 dihydrochloride | MS-023 dihydrochloride | CAS [1992047-64-9] | [1831110-54-3] | [2117404-42-7] | [2108631-19-0] | Non Selective (Arginine Sites Proteins) | PRMT | Inhibitor | Enzymes