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Axon 3613
CAS [380351-29-1]
MF C17H13Br2ClN2OMW 456.56
EN219 is a moderately selective covalent ligand that targets RNF114 (IC50 value of 470 nM) and mimics nimbolide mode of action. EN219 also inhibited RNF114-mediated autoubiquitination and p21 ubiquitination in vitro.
KEYWORDS: EN219 | Supplier | RNF114 ligand | EN 219 | EN-219 | CAS [380351-29-1] | Protein degradation | Ubiquitin Ligase (E3; other) | Ligand | Enzymes | PROTAC | ZNF313 | RING ubiquitin E3
1-(3,5-Bis(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethanone
[380351-29-1]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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