AS2717638

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 3609

CAS [2148339-28-8]

MF C25H25N3O5
MW 447.48

  • Purity: 99%
  • Soluble in DMSO and EtOH
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AS2717638

Description

AS2717638 is a highly potent, selective, orally active, and brain-penetrant lysophosphatidic acid (LPA) receptor 5 antagonist (IC50 value of 0.038 μM). AS2717638 blunted LPA-induced phosphorylation of STAT1 and STAT3, p65, and c-Jun and consequently reduced the secretion of pro-inflammatory cyto-/chemokines (IL-6, TNFα, IL-1β, CXCL10, CXCL2, and CCL5) at non-toxic concentrations. Moreover, AS271763 modulated the expression of intracellular (COX-2 and Arg1) and plasma membrane-located (CD40, CD86, and CD206) polarization markers and attenuated the neurotoxic potential of LPA-activated BV-2 cell-conditioned medium towards CATH.a neurons.

KEYWORDS: AS2717638 | LPA receptor 5 antagonist | AS 2717638 | AS-2717638 | CAS [2148339-28-8] | LPA | Antagonist | Receptors | Analgesia | Neuropathic and inflammatory pain | Allodynia

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Size Unit Price Stock
5 mg €180.00 In Stock
25 mg €720.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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