Micheliolide - MCL

Based on 43 reference(s) in Google Scholar 8 10 43

Axon 3607

CAS [68370-47-8]

MF C15H20O3
MW 248.32

Purity: 100%
Optical purity: Optically pure
Soluble in DMSO

Micheliolide

Description

Micheliolide, a guaianolide sesquiterpene lactone, is an inhibitor of NF-κB pathway activation leading to downregulation of major inflammatory mediator expression such as TNFα and IL-1β. Moreover, MCL has been reported as inhibitor of acute leukemic cells. The prodrug of MCL, ACT001 is also available as Axon 3590.

E Viennois et al. Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer. Lab Invest. 2014 Sep;94(9):950-65.

Q Zhang et al. Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells. J Med Chem. 2012 Oct 25;55(20):8757-69.

NF-κB activation inhibitor

Chemical name

(3aS,9R,9aS,9bS,Z)-9-Hydroxy-6,9-dimethyl-3-methylene-3,3a,4,5,7,8,9,9a-octahydroazuleno[4,5-b]furan-2(9bH)-one

Parent CAS No.

[68370-47-8]

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Size	Unit Price	Stock
5 mg	€120.00	In Stock

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Related Products

Axon ID	Name	Description
2080	EVP 4593	NF-κB activation inhibitor; inhibits SOC pathway	€110.00
2349	JSH 23	Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation	€95.00
3387	NF-κB Activation Inhibitor IV	Potent NF-κB activation inhibitor	€90.00
3590	ACT001	PAI-1 inhibitor	€210.00
3614	Parthenolide	NF-κB activation inhibitor	€90.00

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