YM-244769 dihydrochloride is a highly potent inhibitor of reverse NCX activity (IC50 value of 0.24 μM). Moreover, YM-244769 preferentially inhibited intracellular Na+-dependent 45Ca2+ uptake via NCX3 (IC50 value of 18 nM); the inhibition was 3.8- to 5.3-fold greater than for the uptake via NCX1 or NCX2, but it did not significantly affect extracellular Na+-dependent 45Ca2+ efflux via NCX isoforms. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.

KEYWORDS: YM-244769 dihydrochloride | Supplier | NCX inhibitor | YM 244769 | YM244769 | CAS [1780390-65-9] | [838819-70-8] | [837424-39-2] | Non Selective (Ions; Na+Ca2+) | NCX | Inhibitor | Proteins | Neuroprotection | Anti-ischemic