YM-244769 dihydrochloride

Based on 16 reference(s) in Google Scholar 8 10 16

Axon 3604

CAS [1780390-65-9]

MF C26H22FN3O3.2HCl
MW 516.39

  • Purity: 98%
  • Soluble in DMSO and EtOH
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YM-244769 dihydrochloride

Description

YM-244769 dihydrochloride is a highly potent inhibitor of reverse NCX activity (IC50 value of 0.24 μM). Moreover, YM-244769 preferentially inhibited intracellular Na+-dependent 45Ca2+ uptake via NCX3 (IC50 value of 18 nM); the inhibition was 3.8- to 5.3-fold greater than for the uptake via NCX1 or NCX2, but it did not significantly affect extracellular Na+-dependent 45Ca2+ efflux via NCX isoforms. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.

KEYWORDS: YM-244769 dihydrochloride | Supplier | NCX inhibitor | YM 244769 | YM244769 | CAS [1780390-65-9] | [838819-70-8] | [837424-39-2] | Non Selective (Ions; Na+Ca2+) | NCX | Inhibitor | Proteins | Neuroprotection | Anti-ischemic

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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