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Axon 3591
CAS [2561494-77-5]
MF C24H21N5O4MW 443.45
UNC6934 is a potent and selective chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2 (Kd value of 91 nM). Moreover, UNC6934 disrupted the interaction between NSD2-PWWP1 and nucleosomal H3K36me2 in a dose-dependent manner with an IC50 value of 104 nM. The negative control UNC7145 is also available as Axon 3592.
KEYWORDS: UNC6934 | Supplier | NSD2-PWWP1 antagonist | UNC 6934 | UNC-6934 | CAS [2561494-77-5] | Histone | HMTase | Inhibitor | Enzymes | Multiple myeloma | WHSC1 | MMSET | PHD
N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
[2561494-77-5]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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