ACT001 - Dimethylaminomicheliolide | DMAMCL

Based on 17 reference(s) in Google Scholar 8 10 17

Axon 3590

CAS [1403357-81-2]

MF C17H27NO3
MW 293.40

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N HCl(aq), DMSO and EtOH
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ACT001

Description

Dimethylaminomicheliolide (DMAMCL) is a PAI-1 inhibitor. The inhibition of PAI-1 induces glioma inhibition, and DMAMCL has a synergistic effect with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway. Also, DMAMCL exerts antitumor effects on neuroblastoma (NB) both in vitro and in vivo by suppressing aerobic glycolysis. PFKL could be a potential target of DMAMCL in NB. Its active parent drug Micheliolide (or MCL) is available as Axon 3607.

KEYWORDS: ACT001 | Supplier | PAI-1 inhibitor | Dimethylaminomicheliolide | DMAMCL | ACT 001 | ACT-001 | CAS [1403357-81-2] | [1403357-80-1] | [1582289-91-5] | Serpin | Plasminogen activator inhibitor-1 (PAI-1) | Inhibitor | Enzymes | Phosphofructokinase-1 liver type | PFKL

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Size Unit Price Stock
5 mg €210.00 In Stock
25 mg €800.00 In Stock
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2 x 5 mg €360.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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