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Axon 3590
CAS [1403357-81-2]
MF C17H27NO3MW 293.40
Dimethylaminomicheliolide (DMAMCL) is a PAI-1 inhibitor. The inhibition of PAI-1 induces glioma inhibition, and DMAMCL has a synergistic effect with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway. Also, DMAMCL exerts antitumor effects on neuroblastoma (NB) both in vitro and in vivo by suppressing aerobic glycolysis. PFKL could be a potential target of DMAMCL in NB. Its active parent drug Micheliolide (or MCL) is available as Axon 3607.
KEYWORDS: ACT001 | Supplier | PAI-1 inhibitor | Dimethylaminomicheliolide | DMAMCL | ACT 001 | ACT-001 | CAS [1403357-81-2] | [1403357-80-1] | [1582289-91-5] | Serpin | Plasminogen activator inhibitor-1 (PAI-1) | Inhibitor | Enzymes | Phosphofructokinase-1 liver type | PFKL
(3R,3aS,9R,9aS,9bS,Z)-3-((Dimethylamino)methyl)-9-hydroxy-6,9-dimethyl-3,3a,4,5,7,8,9,9a-octahydroazuleno[4,5-b]furan-2(9bH)-one
[1403357-81-2]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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