NGI-1 - ML414 | N-linked Glycosylation Inhibitor-1

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 3588

CAS [790702-57-7]

MF C17H22N4O3S2
MW 394.51

  • Purity: 98%
  • Soluble in DMSO and EtOH



NGI-1 is a potent and cell-permeable inhibitor of oligosaccharyltransferase (OST) with an AC50 value of 1.1 μM for inhibition of N-linked glycosylation. NGI blocks the transfer of mature glycan precursors to recipient proteins. Moreover, NGI-1 blocks cell surface localization and signaling of the EGFR glycoprotein, but selectively arrests proliferation in only those cell lines that are dependent on EGFR (or FGFR) for survival. NGI-1 also exhibits pan-flaviviral activity.

KEYWORDS: NGI-1 | Supplier | Oligosaccharyltransferase inhibitor | ML414 | N-linked Glycosylation Inhibitor-1 | NGI1 | NGI 1 | ML 414 | ML-414 | CAS [70724-25-3] | Oligosaccharide | Hexosyl-transferases | Inhibitor | Enzymes | Non-small cell lung cancer cells | Senescence | receptor tyrosine kinase-dependent tumors | OST

Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €290.00 In Stock
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Size Unit Price Stock
2 x 10 mg €140.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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