NGI-1 is a potent and cell-permeable inhibitor of oligosaccharyltransferase (OST) with an AC50 value of 1.1 μM for inhibition of N-linked glycosylation. NGI blocks the transfer of mature glycan precursors to recipient proteins. Moreover, NGI-1 blocks cell surface localization and signaling of the EGFR glycoprotein, but selectively arrests proliferation in only those cell lines that are dependent on EGFR (or FGFR) for survival. NGI-1 also exhibits pan-flaviviral activity.

KEYWORDS: NGI-1 | Supplier | Oligosaccharyltransferase inhibitor | ML414 | N-linked Glycosylation Inhibitor-1 | NGI1 | NGI 1 | ML 414 | ML-414 | CAS [70724-25-3] | Oligosaccharide | Hexosyl-transferases | Inhibitor | Enzymes | Non-small cell lung cancer cells | Senescence | receptor tyrosine kinase-dependent tumors | OST