OICR-9429

Based on 13 reference(s) in Google Scholar 8 10 13

Axon 3583

CAS [1801787-56-3]

MF C29H32F3N5O3
MW 555.59

Purity: 98%
Soluble in 0.1N NaOH(aq), 0.1N HCl(aq) and DMSO

OICR-9429

Description

OICR-9429 is a first-in-class, potent, highly selective and cell-active antagonist of the Wdr5-MLL interaction, which is able to elicit a profound disruption of the protein-protein interaction network around Wdr5 and the SET/ MLL HMT complex. OICR-9429 binds to WDR5 with high affinity (KD value of 93 nM).

F Grebien et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol. 2015 Aug;11(8):571-578.

M Getlik et al. Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem. 2016 Mar 24;59(6):2478-96.

First-in-class, potent, highly selective and cell-active antagonist of the Wdr5-MLL interaction

Chemical name

N-(4-(4-Methylpiperazin-1-yl)-3'-(morpholinomethyl)biphenyl-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide

Parent CAS No.

[1801787-56-3]

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Size	Unit Price	Stock
5 mg	€90.00	In Stock
25 mg	€270.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€140.00	In Stock

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Related Products

Axon ID	Name	Description	From price
2411	WDR5-0103	Inhibitor of WD40 repeat protein 5 (WDR5) and associated activity of H3K4 HMTase MLL		€90.00

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