ONC212 caused similar TRAIL/DR5 upregulation and activation of the integrated stress response as ONC201 (Axon 2300), with ONC212 having relatively rapid kinetics. ONC212 is also a mitocan acting on the ClpXP complex and causing collapse of mitochondrial bioenergetics. Moreover, ONC212 activates the orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.

KEYWORDS: ONC212 | Supplier | TRAIL activator | ONC 212 | ONC-212 | CAS [1807861-48-8] | TNF-α | TRAIL | Activator | Proteins | Melanoma | Hepatocellular carcinoma | Pancreatic cancer | Acute myeloid leukemia | AML | Mitochondrial protease ClpP | GPR132 | ClpXP