Based on 14 reference(s) in Google Scholar 8 10 14

Axon 3581

CAS [1807861-48-8]

MF C24H23F3N4O
MW 440.46

  • Purity: 99%
  • Soluble in 0.1N HCl(aq), DMSO and EtOH



ONC212 caused similar TRAIL/DR5 upregulation and activation of the integrated stress response as ONC201 (Axon 2300), with ONC212 having relatively rapid kinetics. ONC212 is also a mitocan acting on the ClpXP complex and causing collapse of mitochondrial bioenergetics. Moreover, ONC212 activates the orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.

KEYWORDS: ONC212 | Supplier | TRAIL activator | ONC 212 | ONC-212 | CAS [1807861-48-8] | TNF-α | TRAIL | Activator | Proteins | Melanoma | Hepatocellular carcinoma | Pancreatic cancer | Acute myeloid leukemia | AML | Mitochondrial protease ClpP | GPR132 | ClpXP

Size Unit Price Stock
5 mg €110.00 In Stock
25 mg €380.00 In Stock
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Size Unit Price Stock
2 x 5 mg €180.00 In Stock
2 x 25 mg €640.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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