Riluzole hydrochloride is a neuroprotective drug that blocks glutamatergic neurotransmission in the CNS. Riluzole inhibits the release of glutamic acid from cultured neurons, from brain slices, and from corticostriatal neurons in vivo. Riluzole also blocks some of the postsynaptic effects of glutamic acid by noncompetitive blockade of N-methyl-D-aspartate (NMDA) receptors. In vivo, riluzole has neuroprotective, anticonvulsant, and sedative properties. The free base is available as Riluzole (Axon 3499).

KEYWORDS: Riluzole hydrochloride | Supplier | Glutamatergic neurotransmission blocker | PK26124 hydrochloride | PK 26124 | PK-26124 | CAS [850608-87-6] | [1744-22-5] | Glutamate | NMDA | Antagonist | Ion Channels | ALS | Amyotrophic lateral sclerosis