THZ1 dihydrochloride

Based on 78 reference(s) in Google Scholar 8 10 78

Axon 3561

CAS [2422107-17-1]

MF C31H28ClN7O2.2HCl
MW 566.05

Purity: 98%
Soluble in DMSO

THZ1 dihydrochloride

Description

THZ1 dihydrochloride is a first covalent inhibitor of CDK7 (IC50 value of 3.2 nM) which employs a unique mechanism, combining ATP-site and allosteric covalent binding, as means of attaining potency and selectivity for CDK7. The free base is also available as THZ1 (Axon 3560).

N Kwiatkowski et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20.

M Wong et al. JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma. Nat Commun. 2019 Jul 25;10(1):3319.

Covalent CDK7 inhibitor

Chemical name

(E)-N-(3-(5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide dihydrochloride

Parent CAS No.

[1604810-83-4]

Order

Size	Unit Price	Stock
5 mg	€110.00	In Stock
25 mg	€330.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1614	SNS 032	CDK inhibitor (2, 7 and 9 specific)	€85.00
2998	Longdaysin	Potent CK1δ/CK1α inhibitor	€125.00
3228	CDK inhibitor CR8	Potent CDK inhibitor (1, 2, 5, 7, and 9 specific)	€130.00
3560	THZ1	Covalent CDK7 inhibitor	€60.00
3756	CT-7001 dihydrochloride	Specific CDK7 inhibitor	Inquire
3525	ETP-47799	Potent CDK8/CDK19 inhibitor	€90.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

THZ1 dihydrochloride

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

THZ1 dihydrochloride

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us