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Axon 3560
CAS [1604810-83-4]
MF C31H28ClN7O2MW 566.05
THZ1 is a first covalent inhibitor of CDK7 (IC50 value of 3.2 nM) which employs a unique mechanism, combining ATP-site and allosteric covalent binding, as means of attaining potency and selectivity for CDK7. The dihydrochloride salt of THZ1 is also available as Axon 3561.
KEYWORDS: THZ1 | Supplier | CDK7 inhibitor | THZ 1 | THZ-1 | CAS [1604810-83-4] | [2422107-17-1] | Cyclin Dependent (CDK) | CDK | Inhibitor | Enzymes | T-cell acute lymphoblastic leukaemia | T-ALL | RUNX1
(E)-N-(3-(5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide
[1604810-83-4]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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