RA-2 is a potent and selective KCa2/3 pan inhibitor with negative-gating modulator properties (IC50 values of 17 and 2 nM for KCa3.1 and KCa2.3, respectively). RA-2 inhibited EDH-type dilations in porcine coronary arteries (PCAs) and was found not to increase blood pressure in telemetry recordings despite reducing heart rate (HR).

KEYWORDS: KCa modulator RA-2 | KCa2/3 inhibitor | KCa modulator RA2 | KCa modulator RA 2 | CAS [1867107-62-7] | Potassium | KCa3.1 | KCa2 | Opener | Ion Channels | Hypotension | Hyperemia | Chronic inflammation