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Homo-PROTAC cereblon degrader 1

Axon 3470
CAS:  2244520-98-5
Purity:  98%
  • Soluble in DMSO
  • MF:  C32H32N6O10
  • MW:  660.63

Description

Homo-PROTAC cereblon degrader 1 is a highly potent and efficient CRBN degrader with only minimal effects on IKZF1 and IKZF3. It induces CRBN-mediated ubiquitination and proteasomal degradation. Homo-PROTAC based on Pomalidomide (Axon 3166).

More Information

Parent CAS No. 2244520-98-5
Chemical Name 4,4'-(2,2'-(Ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(azanediyl)bis(2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione)
SMILES N1C(=O)CCC(N2C(=O)C3C=CC=C(NCCOCCOCCNC4C5C(=O)N(C6C(=O)NC(=O)CC6)C(=O)C=5C=CC=4)C=3C2=O)C1=O
MFCD N.A.
InChi InChI=1S/C32H32N6O10/c39-23-9-7-21(27(41)35-23)37-29(43)17-3-1-5-19(25(17)31(37)45)33-11-13-47-15-16-48-14-12-34-20-6-2-4-18-26(20)32(46)38(30(18)44)22-8-10-24(40)36-28(22)42/h1-6,21-22,33-34H,7-16H2,(H,35,39,41)(H,36,40,42)
InChiKey OXIPFLHBDVDLDS-UHFFFAOYSA-N
CID 137628659
Short Description CRBN degrader

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