Methotrexate - Amethopterin | MTX | 4-Amino-10-methylfolic acid

Based on 54963 reference(s) in Google Scholar 8 10 54963

Axon 3319

CAS [59-05-2]

MF C20H22N8O5
MW 454.44

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in 0.1N NaOH(aq) and DMSO

Methotrexate

Description

Methotrexate is a potent, competitive inhibitor of dihydrofolate reductase (DHFR), and reduces metabolically active intracellular folates decreasing the de novo synthesis of purines and pyrimidines (precursors of DNA and RNA) required for cellular proliferation. Disease-modifying anti-rheumatic drug (DMARD).

KEYWORDS: Methotrexate | supplier | DHFR reductase inhibitor | Amethopterin | MTX | 4-Amino-10-methylfolic acid | CAS [59-05-2] | [15475-56-6] | [7413-34-5] | Dihydrofolic acid | DHFR | Inhibitor | Enzymes | Rheumatoid arthritis | Psoriasis | Multiple sclerosis

Potent, competitive inhibitor of dihydrofolate reductase

Chemical name

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

Parent CAS No.

[59-05-2]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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